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KMID : 1134820080370081079
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Journal of the Korean Society of Food Science and Nutrition
2008 Volume.37 No. 8 p.1079 ~ p.1083
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Antioxidant and Antiproliferative Activity of Pepper (Capsicum annuum L.) Leaves
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Jeon Keon-Wook
Lee Jun-Soo
Choi Young-Min
Lee Seon-Mi
Han Ji-Young
Kim Heung-Tae
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Abstract
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The purposes of this study were aimed to evaluate the antioxidant and antiproliferative activities of water,
methanol, and 70% acetone extracts from pepper leaves. The antioxidant activity was evaluated by ABTS
and DPPH radical scavenging activities, reducing power, and chelating effect. Moreover, the effects of the
extracts on cell proliferation of breast (MCF7), colon (HCT116), and gastric (MKN45) tumor cells were
investigated. Higher extraction yields were obtained with methanol than with 70% acetone and water. Among
the three different solvents, 70% acetone extract showed the highest polyphenolic contents. 70% acetone
extracts showed higher antioxidant activities compared with other extracts. Also, 70% acetone extract of pepper
leaves exhibited higher antiproliferative activity (>80%) against HCT116 and MKN45 cells compared with
other samples at the concentration of 1 mg/mL. These results indicate that pepper leaves may serve as potential
dietary sources of natural antioxidants and antiproliferative substances.
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KEYWORD
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pepper leaves, antioxidant, antiproliferation, polyphenolics
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